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Doron Scientific > Products > Our Products > Protease Substrates for COVID-19 Drug Screening

Protease Substrates for COVID-19 Drug Screening

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For quote and information, please contact with us via email: info@doronscientific.com

 

Covidyte™ Peptide Substrate Series Developed For Researchers In The Fight Against COVID-19
There is an extremely urgent need for the development of specific antiviral therapeutics and vaccines against SARS-CoV-2. The coronavirus main protease, which plays a pivotal role in viral gene expression and replication through the proteolytic processing of replicase polyproteins, is an attractive target for anti-CoV drug design.
The inhibition of viral proteases necessary for proteolytic processing of polyproteins has been a successful strategy in the treatment of human immunodeficiency virus (HIV) and hepatitis C respectively, proving the potential of protease inhibitors for the treatment of viral infections. Similarly, the main protease of SARS-CoV-2 is thought to be essential for viral replication and, therefore, is regarded as promising target for antiviral therapy of Covid-19.
4 extremely effective peptide substrates have been developed for monitoring the intensity of coronavirus proteases via FRET. The Covidyte™ ED450, Covidyte™ EN450, Covidyte™ TF670, and Covidyte™ IF670 peptide substrates provide strong, extended fluorescent signal for searching inhibitors of coronavirus proteases with high sensitivity.
Covidyte™ fluorescent donors Tide Fluor™ 5WS and Edans spectrum curves, visualized using AAT Bioquest Advanced Spectrum Viewer
Covidyte™ IF670
Peptide substrate containing a 14 amino acid sequence that can be cleaved by coronavirus proteases
The dark-FRET peptide contains Tide Quencher™ 5 (TQ5) as a quencher and iFluor™ 670 as a fluorescent donor on the N-and C-terminals respectively
When the peptide is hydrolyzed by coronavirus proteases, the iFluor™ 670 fragment generates significantly enhanced fluorescence since its fluorescence is no longer quenched by TQ5
Covidyte™ TF670
Peptide substrate containing a 14 amino acid sequence that can be cleaved by coronavirus proteases
The dark-FRET peptide contains Tide Quencher™ 5 (TQ5) as a quencher and Tide Fluor™ 5 (TF5) as a fluorescent donor on the N-and C-terminals respectively
When the peptide is hydrolyzed by coronavirus proteases, the TF5 fragment generates significantly enhanced fluorescence since its fluorescence is no longer quenched by TQ5
Covidyte™ ED450
Peptide substrate containing an 11 amino acid sequence that can be cleaved by coronavirus proteases
Covidyte™ EN450
Peptide substrate containing a 14 amino acid sequence that can be cleaved by coronavirus proteases
  • For both Covidyte™ ED450 and Covidyte™ EN450, the dark-FRET peptide contains Dabcyl (quencher) and Edans (donor) on the N-and C-terminals respectively.
  • When the peptide is hydrolyzed by coronavirus proteases, the Edans fragment generates significantly enhanced fluorescence since its fluorescence is no longer quenched by Dabcyl.

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