Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.
This protein carries a polyhistidine tag at the N-terminus, followed by a flag tag. The Avi tag (Avitag™) is inserted in-between the polyhistidine tag and flag tag. The protein has a calculated MW of 51.0 kDa. The protein migrates as 47-57 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Proteins & Peptides
MABSol® Biotin Labeled Proteins
Biotinylated Human CD27 Ligand, His,Avitag,Flag Tag (CDL-H82D7) is expressed from human 293 cells (HEK293). It contains AA Ser 52 - Pro 193 (Accession # P32970-1) trimer Design.
N-6×His & N-Avi & N-Flag
Ser 52 - Pro 193
1.0 EU per μg