Product specifications

Cynomolgus Mucin-1, Fc Tag (MU1-C5252) is expressed from human 293 cells (HEK293). It contains AA Leu 254 – Gly 373 (Accession # XP_005541632.1).

This protein carries a human IgG1 Fc tag at the C-terminus.
The  mature Mucin-1 is a non-covalent heterodimeric complex with the proteolytically cleaved  N-terminal fragment and C-terminal fragment. Each N-terminal fragment and C-terminal fragment has a calculated MW of 7.2 kDa and 32.8 kDa. The protein migrates as 48 kDa (precursor protein) and 40-45 kDa (C-terminus) under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

MU1-C5252-100ug

Product Category

Proteins & Peptides

Material Category

Bio-Markers & CD Antigens

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Cynomolgus

Host

HEK293

Product Type

Bio-Markers & CD Antigens

Format

Powder

Purity

90%

Conjugate

Unconjugated

Bioactivity

Membrane mucins have several functions in epithelial cells including cytoprotection, extravasation during metastases, maintenance of luminal structure, and signal transduction. MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA module domain, a transmembrane domain, and a cytoplasmic domain with potential serine and tyrosine phosphorylation sites. Interacts via its C-terminus with PDZK1 and this interaction appears important for proper localization. Probably plays a role in maintaining homeostasis on mucosal surfaces.

Molecule

Mucin-1

Tag

C-Fc

Expression System

HEK293

Expregion

Leu 254 - Gly 373

Endotoxin Level

1.0 EU per μg

Buffer

50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5

Product Size & Price

Product size: 100ug

Product price: 350

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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