Product specifications

Cynomolgus / Rhesus macaque TIGIT, Fc Tag (TIT-C5254) is expressed from human 293 cells (HEK293). It contains AA Met 89 – Ile 208 (Accession # G7NXM4-1). In the region Met 89 – Ile 208, the AA sequence of Cynomolgus and Rhesus macaque TIGIT are homologus.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 39.9 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

TIT-C5254-50ug

Product Category

Proteins & Peptides

Material Category

Immune Checkpoint Proteins

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Cynomolgus / Rhesus macaque

Host

HEK293

Product Type

Immune Checkpoint Proteins

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

Molecule

TIGIT

Tag

C-Fc

Expression System

HEK293

Expregion

Met 89 - Ile 208

Endotoxin Level

1.0 EU per μg

Buffer

50 mM Tris, 100 mM Glycine, pH7.5

Product Size & Price

Product size: 50ug

Product price: 350

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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