Product specifications

Cynomolgus Siglec-15, Fc Tag (SG5-C5253) is expressed from human 293 cells (HEK293). It contains AA Phe 20 – Thr 263 (Accession # A0A2K5UY47-1).

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

SG5-C5253-1mg

Product Category

Proteins & Peptides

Material Category

Other Recombinant Proteins

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Cynomolgus

Host

HEK293

Product Type

Other Recombinant Proteins

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.

Molecule

Siglec-15

Tag

C-Fc

Expression System

HEK293

Expregion

Phe 20 - Thr 263

Endotoxin Level

1.0 EU per μg

Buffer

50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5

Product Size & Price

Product size: 1mg

Product price: 2540

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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