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Ebolavirus EBOV (subtype Zaire, strain Kikwit-95) Envelope Glycoprotein 1 (GP1) Protein, His Tag

Product specifications

Ebolavirus EBOV (subtype Zaire, strain Kikwit-95) GP1, His Tag (ZE5-V5220) is expressed from human 293 cells (HEK293). It contains AA Ile 33 – Arg 501 (Accession # AAQ55048.1).

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 52.0 kDa. The protein migrates as 95-120 kDa under reducing (R) condition (SDS-PAGE).

Catalog Number

ZE5-V5220-1mg

Product Category

Proteins & Peptides

Material Category

Viral Proteins

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Ebolavirus

Host

HEK293

Product Type

Viral Proteins

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.

Molecule

Glycoprotein / GP (virus)

Tag

C-8×His

Expression System

HEK293

Expregion

Ile 33 - Arg 501

Endotoxin Level

1.0 EU per μg

Buffer

PBS, pH7.4

Product Size & Price

Product size: 1mg

Product price: 1650

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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