Product specifications

FITC-Labeled Human HGF R, His Tag (HGR-HF224) is expressed from human 293 cells (HEK293). It contains AA Glu 25 – Thr 932 (Accession # AAI30421.1).

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 102.7 kDa. The protein migrates as 30-40 kDa, 90-100 kDa and 150 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

HGR-HF224-200ug

Product Category

Proteins & Peptides

Material Category

Fluorescent labeled protein

Supplier

ACROBiosystems

Storage Tempreture

-20℃, aviod light

Species

Human

Host

HEK293

Product Type

Fluorescent labeled protein

Format

Powder

Purity

90%

Conjugate

FITC Labeled

Bioactivity

Hepatocyte growth factor receptor (HGFR) is also known as mesenchymal-epithelial transition factor (MET), c-Met, and is a glycosylated receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGFR protein possesses tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. HGFR is normally expressed by cells of epithelial origin, while expression of HGF is restricted to cells of mesenchymal origin. Upon HGF stimulation, HGFR induces several biological responses that collectively give rise to a program known as invasive growth. Abnormal HGFR activation in cancer correlates with poor prognosis, where aberrantly active HGFR triggers tumor growth, formation of new blood vessels (angiogenesis) that supply the tumor with nutrients, and cancer spread to other organs (metastasis). HGFR is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express HGFR, However, cancer stem cells are thought to hijack the ability of normal stem cells to express HGFR, and thus become the cause of cancer persistence and spread to other sites in the body. Various mutations in the HGFR gene are associated with papillary renal carcinoma. HGFR mediates a complex program known as invasive growth. Activation of HGFR triggers mitogenesis, and morphogenesis.

Molecule

HGF R

Tag

C-8×His

Expression System

HEK293

Expregion

Glu 25 - Thr 932

Endotoxin Level

1.0 EU per μg

Buffer

PBS, pH7.4

Product Size & Price

Product size: 200ug

Product price: 2180

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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