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Human ACHE / Acetylcholinesterase Protein, His Tag (active enzyme)

Product specifications

The enzyme acetylcholinesterase, also known as AChE or acetylhydrolase, is the primary cholinesterase in the body. It is a serine hydrolase whose primary function is to catalyzes the breakdown of acetylcholine(ACh) and of some other choline esters that function as neurotransmitters. AChE is found at mainly neuromuscular junctions and in chemical synapses of the cholinergic type, where its activity serves to terminate synaptic transmission. Acetylcholine deficit has been found in Alzheimer’s disease (AD) ans is associated with cognetive decline. Therefore, AChE has been reported to be a viable therapeutic target for the treatment of AD and other dementias. To this end, acetylcholinesterase inhibitors (AChEIs) are commonly used.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 66.5 kDa. The protein migrates as 65-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

AHE-H52H3-500ug

Product Category

Proteins & Peptides

Material Category

Other Recombinant Proteins

Supplier

ACROBiosystems

Species

Human

Host

HEK293

Format

Powder

Purity

95%

Conjugate

Unconjugated

Source

Human ACHE, His Tag (AHE-H52H3) is expressed from human 293 cells (HEK293). It contains AA Glu 32 - Leu 614 (Accession # P22303-1).

Molecule

ACHE

Tag

C-10×His

Expregion

Glu 32 - Leu 614

Endotoxin Level

1.0 EU per μg

Buffer

PBS, pH7.4

Product Size & Price

Product size: 500ug

Product price: 3420

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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