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Human Angiopoietin-2 / ANGPT2 (275-496) Protein, His Tag

Product specifications

Human Angiopoietin-2 (275-496), His Tag (AN2-H5242) is expressed from human 293 cells (HEK293). It contains AA Lys 275 – Phe 496 (Accession # AAI26201.1).

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 26.3 kDa. The protein migrates as 30-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

AN2-H5242-500ug

Product Category

Proteins & Peptides

Material Category

Cytokines&Growth Factors

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

HEK293

Product Type

Cytokines&Growth Factors

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Angiopoietin-2 is also known as ANGPT2, AGPT2, ANG2, and is a secreted glycoprotein that plays a complex role in angiogenesis and inflammation. Ang2 is widely expressed during development, but it is restricted postnatally to highly angiogenic tissues such as the placenta, ovaries, and uterus. It is particularly abundant in vascular endothelial cells (EC) where it is stored in intracellular Weibel Palade bodies. Both Ang2 and the related Angiopoietin1 (Ang1) are ligands for the receptor tyrosine kinase Tie 2. Ang2 functions as a proangiogenic factor, although it can also induce EC death and vessel regression. Upon its release from quiescent EC, it regulates vascular remodeling by promoting EC survival, proliferation, and migration and destabilizing the interaction between EC and perivascular cells. Ang2 is required for postnatal vascular remodeling, and it cooperates with Ang1 during lymphatic vessel development. It mediates the upregulation of ICAM1 and VCAM1 on EC, which facilitates the adhesion of leukocytes during inflammation. Ang2 competitively inhibit Ang1-induced endothelial cell responses mediated by Tie2, and reduces vascular integrity. But the role of Ang2 is controversial since the opposite outcomes has been reported in other studies. Over-expression of Ang2 disrupts the vascular remodeling, induce endothelial cell apoptosis, and may play an important regulating role in tumor angiogenesis. Ang2 also promotes the neuronal differentiation and migration of subventricular zone progenitor cells.

Molecule

Angiopoietin-2

Tag

N-6×His

Expression System

HEK293

Expregion

Lys 275 - Phe 496

Endotoxin Level

1.0 EU per μg

Buffer

20 mM MOPS, 150 mM NaCl, pH7.5

Product Size & Price

Product size: 500ug

Product price: 1650

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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