Product specifications

Human Angiopoietin-like 3, His Tag (AN3-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 17 – Glu 460 (Accession # Q9Y5C1-1).

This protein carries a polyhistidine tag at the C-terminus. This protein contains a furin-like convertase cleavage site, 221-RAPR-224, and will be partially processed into N and C-terminal fragment with calculated MW of 24.3 kDa and 29.4 kDa respectively. The protein migrates as 55-70 kDa (full lengh), 31-33 kDa (C-terminal fragment) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

AN3-H52H3-100ug

Product Category

Proteins & Peptides

Material Category

Cytokines&Growth Factors

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

HEK293

Product Type

Cytokines&Growth Factors

Format

Powder

Purity

90%

Conjugate

Unconjugated

Bioactivity

Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.

Molecule

Angiopoietin-like 3

Tag

C-10×His

Expression System

HEK293

Expregion

Ser 17 - Glu 460

Endotoxin Level

1.0 EU per μg

Buffer

PBS, 0.05% CHAPS, pH7.4

Product Size & Price

Product size: 100ug

Product price: 335

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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