Product specifications

Human ANXA5, Tag Free (AN5-H5118) is expressed from E. coli cells. It contains AA Met 1 – Asp 320 (Accession # P08758-1).

This protein carries no “tag”. The protein has a calculated MW of 35.9 kDa. The protein migrates as 33-35 kDa under reducing (R) condition (SDS-PAGE).

Catalog Number

AN5-H5118-100ug

Product Category

Proteins & Peptides

Material Category

Other Recombinant Proteins

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

E. coli

Product Type

Other Recombinant Proteins

Format

Powder

Purity

98%

Conjugate

Unconjugated

Bioactivity

Annexin A5 is a phospholipid binding protein, which binds with high affinity and selectivity to PS in the presence of calcium. PS is predominantly located in membrane leaflets, which face the cytosol. However, recent findings show that each cell type has the molecular machinery to expose PS at its cell surface. This machinery is activated during the execution of apoptosis. Once PS is exposed at the cell surface it exhibits procoagulant and proinflammatory activities. Annexin A5 will bind to the PS-exposing apoptotic cell and can inhibit the procoagulant and proinflammatory activities of the dying cell. Annexin A5 has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation. The presence of antibodies to Annexin A5 is associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions and systemic sclerosis (SSc).

Molecule

Annexin A5

Tag

Native

Expression System

E. coli

Expregion

Met 1 - Asp 320

Endotoxin Level

1.0 EU per μg

Buffer

PBS, pH7.4

Product Size & Price

Product size: 100ug

Product price: 220

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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