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Human CTLA-4 / CD152 Protein, mouse IgG2a Fc Tag, low endotoxin

Product specifications

Human CTLA-4 Protein, Mouse IgG2a Fc Tag (CT4-H52A4) is expressed from human 293 cells (HEK293). It contains AA Ala 37 – Phe 162 (Accession # P16410-1).

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation and 100 kDa under non-reducing (NR) condition.

Catalog Number

CT4-H52A4-100ug

Product Category

Proteins & Peptides

Material Category

Immune Checkpoint Proteins

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

HEK293

Product Type

Immune Checkpoint Proteins

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. The protein contains an extracellular V domain, a transmembrane domain, and a cytoplasmic tail. Alternate splice variants, encoding different isoforms. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function. Fusion proteins of CTLA4 and antibodies (CTLA4-Ig) have been used in clinical trials for rheumatoid arthritis.

Molecule

CTLA-4

Tag

C-mFc(mIgG2a)

Expression System

HEK293

Expregion

Ala 37 - Phe 162

Endotoxin Level

0.1 EU per μg

Buffer

50 mM Tris, 100 mM Glycine, pH7.5

Product Size & Price

Product size: 100ug

Product price: 290

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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