Product specifications

Human CXADR, His Tag (CXR-H5222) is expressed from human 293 cells (HEK293). It contains AA Leu 20 – Gly 237 (Accession # NP_001329.1).

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 24.9 kDa. The protein migrates as 32-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

CXR-H5222-1mg

Product Category

Proteins & Peptides

Material Category

Other Recombinant Proteins

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

HEK293

Product Type

Other Recombinant Proteins

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Coxsackie virus and adenovirus receptor (CXADR) is also known as CAR, is a type I transmembrane glycoprotein for group B coxsackie viruses and subgroup C adenoviruses, and belongs to the CTX family of the Ig superfamily. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins such as: fibronectin, agrin, laminin-1 and tenascin-R. Human CXADR protein contains a signal sequence, a extracellular domain (ECD) with a V­ type (D1) and a C2­ type (D2) Ig­like domain, a  transmembrane segment and a intracellular domain. D1 is thought to be responsible for homodimer formation in trans within tight junctions, and is necessary and sufficient for adenovirus binding. Variants of CXADR are attached to the cell membrane by a GPI- anchor.

Molecule

CXADR

Tag

C-6×His

Expression System

HEK293

Expregion

Leu 20 - Gly 237

Endotoxin Level

1.0 EU per μg

Buffer

PBS, pH7.4

Product Size & Price

Product size: 1mg

Product price: 1580

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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