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Human / Cynomolgus / Rhesus macaque ROR1 (39-151, Ig-like domain) Protein, His Tag

Product specifications

Human / Cynomolgus / Rhesus macaque ROR1 (39-151, Ig-like domain), His Tag (RO1-H5221) is expressed from human 293 cells (HEK293). It contains AA Glu 39 – Gly 151 (Accession # Q01973-1). In the region Gln 30 – Glu 403, the AA sequence of Human, Cynomolgus and Rhesus macaque ROR1 are homologus.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 13.7 kDa. The protein migrates as 25-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

RO1-H5221-1mg

Product Category

Proteins & Peptides

Material Category

Bio-Markers & CD Antigens

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human / Cynomolgus / Rhesus macaque

Host

HEK293

Product Type

Bio-Markers & CD Antigens

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Tyrosine-protein kinase transmembrane receptor ROR1 is also known as Neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), which belongs to the protein kinase superfamily or tyr protein kinase family or ROR subfamily. ROR1 contains 1 FZ (frizzled) domain, 1 Ig-like C2-type (immunoglobulin-like) domain, 1 kringle domain, 1 protein kinase domain. ROR1 is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. ROR1 could interact with casein kinase 1 epsilon (CK1ε) to activate phosphoinositide 3-kinase-mediated AKT phosphorylation and cAMP-response-element-binding protein (CREB), which was associated with enhanced tumor-cell growth.

Molecule

ROR1

Tag

C-8×His

Expression System

HEK293

Expregion

Glu 39 - Gly 151

Endotoxin Level

0.1 EU per μg

Buffer

PBS, pH7.4

Product Size & Price

Product size: 1mg

Product price: 3080

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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