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Human Fas Ligand / TNFSF6 Protein, His Tag, premium grade

Product specifications

Human Fas Ligand, His Tag, premium grade (FAL-H5241) is expressed from human 293 cells (HEK293). It contains AA Pro 134 – Leu 281 (Accession # AAH17502.1).

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.8 kDa. The protein migrates as 25-33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

FAL-H5241-1mg

Product Category

Proteins & Peptides

Material Category

Bio-Markers & CD Antigens

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

HEK293

Product Type

Bio-Markers & CD Antigens

Format

Powder

Purity

90%

Conjugate

Unconjugated

Bioactivity

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

Molecule

Fas Ligand

Tag

N-10×His

Expression System

HEK293

Expregion

Pro 134 - Leu 281

Endotoxin Level

0.1 EU per μg

Buffer

PBS, pH7.4

Product Size & Price

Product size: 1mg

Product price: 3410

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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