Product specifications

Human Frizzled-2, Fc Tag (FZ2-H5251) is expressed from human 293 cells (HEK293). It contains AA Gln 24 – Ser 156 (Accession # AAI13403).

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 41.7 kDa. The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

FZ2-H5251-1mg

Product Category

Proteins & Peptides

Material Category

Bio-Markers & CD Antigens

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

HEK293

Product Type

Bio-Markers & CD Antigens

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

Molecule

Frizzled-2

Tag

C-Fc

Expression System

HEK293

Expregion

Gln 24 - Ser 156

Endotoxin Level

1.0 EU per μg

Buffer

Tris with Glycine, Arginine and NaCl, pH7.5

Product Size & Price

Product size: 1mg

Product price: 1980

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Order Details

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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