Product specifications

Human HMGB1 Protein, Mouse IgG2a Fc Tag (HM1-H5255) is expressed from human 293 cells (HEK293). It contains AA Gly 2 – Glu 215 (Accession # P09429-1).

This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 51.6 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

HM1-H5255-100ug

Product Category

Proteins & Peptides

Material Category

Bio-Markers & CD Antigens

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

HEK293

Product Type

Bio-Markers & CD Antigens

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.

Molecule

HMGB1

Tag

N-mFc(mIgG2a)

Expression System

HEK293

Expregion

Gly 2 - Glu 215

Endotoxin Level

0.1 EU per μg

Buffer

50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5

Product Size & Price

Product size: 100ug

Product price: 350

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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