Product specifications

Human IL-1 beta, premium grade (ILB-H4110) is expressed from E. coli cells. It contains AA Ala 117 – Ser 269 (Accession # P01584-1).

This protein carries no “tag”. The protein has a calculated MW of 17.5 kDa. The protein migrates as 18 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Catalog Number

ILB-H4110-20ug

Product Category

Proteins & Peptides

Material Category

Cytokines&Growth Factors

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

E. coli

Product Type

Cytokines&Growth Factors

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta. IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Molecule

IL-1 beta

Tag

Native

Expression System

E. coli

Expregion

Ala 117 - Ser 269

Endotoxin Level

0.01 EU per μg

Buffer

PBS, pH7.4

Product Size & Price

Product size: 20ug

Product price: 160

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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