Product specifications

Human IL-15, premium grade (IL5-H4117) is expressed from E.coli cells. It contains AA Asn 49 – Ser 162 (Accession # P40933-1).

This protein carries no “tag”. The protein has a calculated MW of 12.9 kDa. The protein migrates as 13 kDa±3 kDa under reducing (R) condition (SDS-PAGE).

Catalog Number

IL5-H4117-1mg

Product Category

Proteins & Peptides

Material Category

Cytokines&Growth Factors

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

E. coli

Product Type

Cytokines&Growth Factors

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.

Molecule

IL-15

Tag

Native

Expression System

E. coli

Expregion

Asn 49 - Ser 162

Endotoxin Level

0.01 EU per μg

Buffer

25 mM Histidine, pH6.2

Product Size & Price

Product size: 1mg

Product price: 2420

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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