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Human Integrin alpha M beta 2 (ITGAM&ITGB2) Heterodimer Protein, His Tag&Tag Free

Product specifications

Human ITGAM&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H52W4) is expressed from human 293 cells (HEK293). It contains AA Phe 17 – Asn 1105 (ITGAM) & Gln 23 – Asn 700 (ITGB2) (Accession # P11215-2 (ITGAM) & P05107-1 (ITGB2)).

Human ITGAM&ITGB2 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAM and ITGB2, has a calculated MW of 127.2 kDa (ITGAM) and 80.2 kDa (ITGB2). Subunit ITGAM is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus. The non-reducing (NR) protein migrates as 150-180 kDa (ITGAM) and 85-95 kDa (ITGB2) respectively due to glycosylation.

Catalog Number

IT2-H52W4-1mg

Product Category

Proteins & Peptides

Material Category

Bio-Markers & CD Antigens

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

HEK293

Product Type

Bio-Markers & CD Antigens

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.

Molecule

Integrin alpha M beta 2

Tag

C-10×His | Native

Expression System

HEK293

Expregion

Phe 17 - Asn 1105 (ITGAM) & Gln 23 - Asn 700 (ITGB2)

Endotoxin Level

1.0 EU per μg

Buffer

50 mM Tris, 150 mM NaCl, pH7.5

Product Size & Price

Product size: 1mg

Product price: 3170

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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