Product specifications

Human LRP-5, Mouse IgG2a Fc Tag (LR5-H5254) is expressed from human 293 cells (HEK293). It contains AA Glu 644 – Gln 1263 (Accession # O75197-1 ).

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 96.6 kDa. The protein migrates as 95-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

LR5-H5254-1mg

Product Category

Proteins & Peptides

Material Category

Other Recombinant Proteins

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

HEK293

Product Type

Other Recombinant Proteins

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.

Molecule

LRP-5

Tag

C-mFc(mIgG2a)

Expression System

HEK293

Expregion

Glu 644 - Gln 1263

Endotoxin Level

0.1 EU per μg

Buffer

51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5

Product Size & Price

Product size: 1mg

Product price: 2540

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Order Details

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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