Product specifications

Human NPC2, His Tag (NP2-H52H1) is expressed from human 293 cells (HEK293). It contains AA Glu 20 – Leu 151 (Accession # P61916-1).

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.5 kDa. The protein migrates as 21 kDa and 24-27 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

NP2-H52H1-100ug

Product Category

Proteins & Peptides

Material Category

Other Recombinant Proteins

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

HEK293

Product Type

Other Recombinant Proteins

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Niemann-Pick disease type C2 protein (NPC2) is also known as epididymal secretory protein E1 and human epididymis-specific protein 1 (HE1). NPC2 is a intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. Also,NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Furthermore,the secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.

Molecule

Niemann-Pick Type C2

Tag

C-10×His

Expression System

HEK293

Expregion

Glu 20 - Leu 151

Endotoxin Level

1.0 EU per μg

Buffer

PBS, pH7.4

Product Size & Price

Product size: 100ug

Product price: 250

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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