Product specifications

Human NOTCH3, Fc Tag (NO3-H5255) is expressed from human 293 cells (HEK293). It contains AA Ala 40 – Glu 467 (Accession # Q9UM47-1).

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 71.4 kDa. The protein migrates as 65-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

NO3-H5255-1mg

Product Category

Proteins & Peptides

Material Category

Other Recombinant Proteins

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

HEK293

Product Type

Other Recombinant Proteins

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Notch3 is one of four mammalian Notch proteins, which act as signalling receptors and involve in developmental patterning, cell fate decisions, regulation of cell survival and proliferation. Notch3 could interact with membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Via ligand activation, notch intracellular domain (NICD) is released and forms a transcriptional activator RBPJ/RBPSUH complex, which activates genes of the enhancer of split locus. Consequently, the activation of Notch3 can lead to the implementation of differentiation, proliferation and apoptotic programs

Molecule

NOTCH3

Tag

C-Fc

Expression System

HEK293

Expregion

Ala 40 - Glu 467

Endotoxin Level

1.0 EU per μg

Buffer

50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5

Product Size & Price

Product size: 1mg

Product price: 2540

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Order Details

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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