Product specifications

Human Siglec-1, His Tag (SG1-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 20 – Gln 1641 (Accession # Q9BZZ2-1).

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 175.1 kDa. The protein migrates as 200-220 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

SG1-H52H3-1mg

Product Category

Proteins & Peptides

Material Category

Bio-Markers & CD Antigens

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Human

Host

HEK293

Product Type

Bio-Markers & CD Antigens

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Alternate names for sialoadhesin include siglec-1 and CD169 (cluster of differentiation 169). Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. It is defined as an I-type lectin, since it contains 17 immunoglobulin (Ig) domains (one variable domain and 16 constant domains), and thus also belongs to the immunoglobulin superfamily (IgSF). Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells.

Molecule

Siglec-1

Tag

C-10×His

Expression System

HEK293

Expregion

Ser 20 - Gln 1641

Endotoxin Level

1.0 EU per μg

Buffer

MES,NaCl,pH7.5

Product Size & Price

Product size: 1mg

Product price: 2667

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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