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Mouse Integrin alpha 10 beta 1 (ITGA10&ITGB1) Heterodimer Protein, His Tag&Tag Free

Product specifications

Mouse ITGA10&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-M52W4) is expressed from human 293 cells (HEK293). It contains AA Phe 23 – Thr 1118 (ITGA10) & Gln 21 – Asp 728 (ITGB1) (Accession # E9PXZ3-1 (ITGA10) & P09055-1 (ITGB1)).

Mouse ITGA10&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA10 and ITGB1, has a calculated MW of 126.6 kDa (ITGA10) and 83.5 kDa (ITGB1). Subunit ITGA10 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The reducing (R) protein migrates as 150-170 kDa (ITGA10) and 100-130 kDa (ITGB1) respectively due to glycosylation.

Catalog Number

IT1-M52W4-1mg

Product Category

Proteins & Peptides

Material Category

Bio-Markers & CD Antigens

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

Mouse

Host

HEK293

Product Type

Bio-Markers & CD Antigens

Format

Powder

Purity

90%

Conjugate

Unconjugated

Bioactivity

Human integrin alpha(10)I domain as a recombinant protein to reveal its ligand binding specificity. In general, alpha(10)I did recognize collagen types I-VI and laminin-1 in a Mg(2+)-dependent manner, whereas its binding to tenascin was only slightly better than to albumin. Alpha 10 beta 1 is a known collagen-binding I domain integrin, in addition to α1β1, α2β1 and α11β1. GROGER found in the N-terminal domain of collagens I and III, is only weakly recognised by α10β1, an important collagen receptor on chondrocytes, contrasting with the other collagen-binding integrins.

Molecule

Integrin alpha 10 beta 1

Tag

C-10×His | Native

Expression System

HEK293

Expregion

Phe 23 - Thr 1118 (ITGA10) & Gln 21 - Asp 728 (ITGB1)

Endotoxin Level

1.0 EU per μg

Buffer

50 mM Tris, 150 mM NaCl, pH7.5

Product Size & Price

Product size: 1mg

Product price: 3170

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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