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PE-Labeled Human EGFRvIII Protein, His Tag (Site-specific conjugation)

Product specifications

PE-Labeled Human EGFRvIII, His Tag (EGI-HP2E3) is produced via site-specific conjugation of PE to Human EGFRvIII (25-378), His Tag under optimal conditions with a proprietary technology. Human EGFRvIII, His Tag (EGI-HP2E3) is expressed from human 293 cells (HEK293). It contains AA Leu 25 – Ser 378 (Accession # NP_001333870.1).

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 42.2 kDa.

Catalog Number

EGI-HP2E3-200tests

Product Category

Proteins & Peptides

Material Category

Fluorescent labeled protein

Supplier

ACROBiosystems

Storage Tempreture

-20℃, aviod light

Species

Human

Host

HEK293

Product Type

Fluorescent labeled protein

Format

Powder

Purity

N/A

Conjugate

PE Labeled

Bioactivity

The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer. The type III EGF deletion mutant receptor (EGFRvIII) is the most common mutation and was first identified in primary human glioblastoma tumors. This tumor-specific antigen is ligand-independent, contains a constitutively active tyrosine kinase domain, and has been shown to be present in a number of human malignancies. EGFRvIII has been selected as a target for CAR-modified T-cell studies in recent years.

Molecule

EGFRvIII

Tag

C-10×His

Expression System

HEK293

Expregion

Leu 25 - Ser 378

Endotoxin Level

N/A

Buffer

PBS, 0.5% BSA, pH7.4

Product Size & Price

Product size: 200tests

Product price: 2080

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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