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PE-Labeled Human GUCY2C / Guanylyl cyclase C Protein, His Tag (Site-specific conjugation)

Product specifications

PE-Labeled Human GUCY2C, His Tag (GUC-HP2E3) is produced via site-specific conjugation of PE to Human GUCY2C, His Tag under optimal conditions with a proprietary technology. Human GUCY2C, His Tag is expressed from human 293 cells (HEK293). It contains AA Ser 24 – Gln 430 (Accession # P25092-1).

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 49.6 kDa.

Catalog Number

GUC-HP2E3-200tests

Product Category

Proteins & Peptides

Material Category

Fluorescent labeled protein

Supplier

ACROBiosystems

Storage Tempreture

-20℃, aviod light

Species

Human

Host

HEK293

Product Type

Fluorescent labeled protein

Format

Powder

Purity

N/A

Conjugate

PE Labeled

Bioactivity

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

Molecule

GUCY2C

Tag

C-10×His

Expression System

HEK293

Expregion

Ser 24 - Gln 430

Endotoxin Level

N/A

Buffer

PBS, 0.5% BSA, pH7.4

Product Size & Price

Product size: 200tests

Product price: 1980

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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