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SARS-CoV-2 Nucleocapsid protein (D63G, R203M, D377Y), His Tag

Product specifications

SARS-CoV-2 Nucleocapsid protein (D63G, R203M, D377Y), His Tag (NUN-C52Hs) is expressed from human 293 cells (HEK293). It contains AA Met 1 – Ala 419 (Accession # QHO62115.1 (D63G, R203M, D377Y )). The mutations (D63G, R203M, D377Y) were identified in the SARS-CoV-2 Delta lineages (Pango lineage: B.1.617.2; GISAID clade: 21A, 21I, 21J; Nextstrain clade: G/478K.V1).

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 47.3 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

NUN-C52Hs-1mg

Product Category

Proteins & Peptides

Material Category

Viral Proteins

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

SARS-CoV-2

Host

HEK293

Product Type

Viral Proteins

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

Nucleocapsid (N) protein is the most abundant protein found in coronavirus. CoV N protein is a highly immunogenic phosphoprotein important for viral genome replication and modulation of cell signaling pathways. It was first identified by a research team while they were screening for ADP-ribosylated proteins during coronavirus (CoV) infection (Grunewald M. E., et al. 2017, Virology; 517: 62-68). The array of diverse functional activities accommodated in N protein makes it more than a structural protein but also an interesting target in the development of antiviral therapeutics. Because of the conservation of N protein sequence and its strong immunogenicity, N protein of coronavirus is chosen as a diagnostic tool.

Molecule

Nucleocapsid protein

Tag

C-6×His

Expression System

HEK293

Expregion

Met 1 - Ala 419

Endotoxin Level

1.0 EU per μg

Buffer

PBS,pH7.3 with 0.2 M Arginine

Product Size & Price

Product size: 1mg

Product price: 2860

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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