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SARS-CoV-2 Spike S2 protein, His Tag (BA.1/Omicron)

Product specifications

SARS-CoV-2 S2 protein, His Tag (BA.1/Omicron) (S2N-C52Hf) is expressed from human 293 cells (HEK293). It contains AA Ser 686 – Pro 1213 (Accession # QHD43416.1 (N764K, D796Y, N856K, Q954H, N969K, L981F, F817P, A892P, A899P, A942P, K986P, V987P)). The mutations are identified on the SARS-CoV-2 Omicron variant (Pango lineage: BA.1; GISAID clade: GRA; Nextstrain clade: 21K). Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) are introduced to prevent the formation of aggregates in the course of protein production.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 59.9 kDa. The protein migrates as 70-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Catalog Number

S2N-C52Hf-1mg

Product Category

Proteins & Peptides

Material Category

Viral Proteins

Supplier

ACROBiosystems

Storage Tempreture

-20℃

Species

SARS-CoV-2

Host

HEK293

Product Type

Viral Proteins

Format

Powder

Purity

95%

Conjugate

Unconjugated

Bioactivity

It's been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.

Molecule

Spike S2

Tag

C-10×His

Expression System

HEK293

Expregion

Ser 686 - Pro 1213

Endotoxin Level

1.0 EU per μg

Buffer

PBS, pH7.4

Product Size & Price

Product size: 1mg

Product price: 2200

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Limitations

Please note: All products are “FOR RESEARCH USE ONLY”. NOT FOR USE IN DIAGNOSTIC PROCEDURES or Human or Veterinary or Food.

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