Human CD20 / MS4A1 Full Length Protein, Flag,His Tag (Detergent)
Product specifications
Human CD20 Full Length Protein, Flag,His Tag (CD0-H52D5) is expressed from human 293 cells (HEK293). It contains AA Met 1 – Pro 297 (Accession # P11836-1).
This protein . The protein has a calculated MW of 36.0 kDa . The protein migrates as 40-43 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Catalog Number
CD0-H52D5-20ug
Product Category
Proteins & Peptides
Material Category
Bio-Markers & CD Antigens
Supplier
ACROBiosystems
Storage Tempreture
-70℃
Species
Human
Host
HEK293
Product Type
Bio-Markers & CD Antigens
Format
Liquid
Purity
90%
Conjugate
Unconjugated
Bioactivity
B-lymphocyte antigen CD20 is also known as B-lymphocyte surface antigen B1, Leukocyte surface antigen Leu-16, Membrane-spanning 4-domains subfamily A member 1 and MS4A1, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. CD20 is expressed on all stages of B cell development except the first and last; it is present from late pro-B cells through memory cells, but not on either early pro-B cells or plasma blasts and plasma cells. It is found on B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells. The protein has no known natural ligand and its function is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that it acts as a calcium channel in the cell membrane. CD20 / MS4A1 is the target of the monoclonal antibodies (mAb) rituximab, Ibritumomab tiuxetan, and tositumomab, which are all active agents in the treatment of all B cell lymphomas and leukemias. Defects in CD20 / MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5); also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen.
Molecule
CD20
Tag
N-Flag & C-12×His
Expression System
HEK293
Expregion
Met 1 - Pro 297
Endotoxin Level
1.0 EU per μg
Buffer
50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
