Cynomolgus IL-5 Protein, His Tag
Product specifications
Cynomolgus IL-5, His Tag (IL5-C52H3) is expressed from human 293 cells (HEK293). It contains AA Ile 20 – Ser 134 (Accession # A0A2K5U1E7-1).
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 15.0 kDa. The protein migrates as 19-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Catalog Number
IL5-C52H3-1mg
Product Category
Proteins & Peptides
Material Category
Cytokines&Growth Factors
Supplier
ACROBiosystems
Storage Tempreture
-20℃
Species
Cynomolgus
Host
HEK293
Product Type
Cytokines&Growth Factors
Format
Powder
Purity
90%
Conjugate
Unconjugated
Bioactivity
Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells. IL-5 is a 115-amino acid (in human, 133 in the mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. Interleukin-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. Given the high concordance of eosinophils and, in particular, allergic asthma pathology, it has been widely speculated that eosinophils have an important role in the pathology of this disease. Drugs that target IL-5 are mepolizumab and reslizumab.
Molecule
IL-5
Tag
N-10×His
Expression System
HEK293
Expregion
Ile 20 - Ser 134
Endotoxin Level
1.0 EU per μg
Buffer
PBS, pH7.4
