Human TSLP (R127A, R130A) Protein, Mouse IgG2a Fc Tag
Product specifications
Human TSLP (R127A, R130A) Protein, Mouse IgG2a Fc Tag (TSP-H5255) is expressed from human 293 cells (HEK293). It contains AA Tyr 29 – Gln 159 (Accession # Q969D9-1 (R127A, R130A)).
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 41.6 kDa. The protein migrates as 50-58 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Catalog Number
TSP-H5255-1mg
Product Category
Proteins & Peptides
Material Category
Other Recombinant Proteins
Supplier
ACROBiosystems
Storage Tempreture
-20℃
Species
Human
Host
HEK293
Product Type
Other Recombinant Proteins
Format
Powder
Purity
95%
Conjugate
Unconjugated
Bioactivity
Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine involved in the pathology of inflammatory skin diseases, and is widely expressed by epithelial cells. Human TSLP cDNA encodes a 159 amino acid (aa) residue precursor protein with a 28 aa signal sequence (4, 5). Human TSLP has been shown to developing nondeletional central tolerance, amplifying epithelium-induced class switching, inducing atopic diseases and maintaining intestinal noninflammatory environment. Among diverse cells responding to Human TSLP, CD11c+ dendritic cells are the most obviously characterized target cells.
Molecule
TSLP
Tag
C-mFc(mIgG2a)
Expression System
HEK293
Expregion
Tyr 29 - Gln 159
Endotoxin Level
0.1 EU per μg
Buffer
PBS, pH7.4
