Mouse SCF / KITLG Protein, His Tag
Product specifications
Mouse SCF, His Tag (SCF-M5228) is expressed from human 293 cells (HEK293). It contains AA Lys 26 – Ala 189 (Accession # NP_038626).
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 19.5 kDa. The protein migrates as 19-30 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
Catalog Number
SCF-M5228-1mg
Product Category
Proteins & Peptides
Material Category
Cytokines&Growth Factors
Supplier
ACROBiosystems
Storage Tempreture
-20℃
Species
Mouse
Host
HEK293
Product Type
Cytokines&Growth Factors
Format
Powder
Purity
95%
Conjugate
Unconjugated
Bioactivity
Stem Cell Factor is also known as SCF, kit-ligand, KL, steel factor, KITLG, FPH2, KL-1, Kitl, MGF, SCF, SF, or SHEP7, and is a cytokine that binds to the c-Kit receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. This cytokine plays an important role in hematopoiesis (formation of blood cells), spermatogenesis, and melanogenesis. The soluble and transmembrane forms of the protein are formed by alternative splicing of the same RNA transcript.Soluble and transmembrane SCF is produced by fibroblasts and endothelial cells. Soluble SCF has a molecular weight of 18,5 KDa and forms a dimer. SCF plays an important role in the hematopoiesis during embryonic development. Sites where hematopoiesis takes place, such as the fetal liver and bone marrow, all express SCF. During development, the presence of the SCF also plays an important role in the localization of melanocytes, cells that produce melanin and control pigmentation. SCF plays a role in the regulation of HSCs in the stem cell niche in the bone marrow. SCF may be used along with other cytokines to culture HSCs and hematopoietic progenitors. The expansion of these cells ex-vivo (outside the body) would allow advances in bone-marrow transplantation, in which HSCs are transferred to a patient to re-establish blood formation.
Molecule
SCF
Tag
C-9×His
Expression System
HEK293
Expregion
Lys 26 - Ala 189
Endotoxin Level
1.0 EU per μg
Buffer
PBS, pH7.4
