The finding that lipofection is also attacked by the defense measures of the innate immune system led us to develop the K2® Transfection System, consisting of the K2® Transfection Reagent and the K2® Multiplier. The K2® Transfection Reagent is based on powerful cationic lipids (as liposomes), while the Multiplier decreases the cells’ ability to detect nucleic acids. The K2® Transfection System is therefore a further development of the transfection reagent METAFECTENE® PRO.