Human Fas Ligand / TNFSF6 Protein, His Tag, premium grade
Product specifications
Human Fas Ligand, His Tag, premium grade (FAL-H5241) is expressed from human 293 cells (HEK293). It contains AA Pro 134 – Leu 281 (Accession # AAH17502.1).
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.8 kDa. The protein migrates as 25-33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
Catalog Number
FAL-H5241-50ug
Product Category
Proteins & Peptides
Material Category
Bio-Markers & CD Antigens
Supplier
ACROBiosystems
Storage Tempreture
-20℃
Species
Human
Host
HEK293
Product Type
Bio-Markers & CD Antigens
Format
Powder
Purity
90%
Conjugate
Unconjugated
Bioactivity
Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.
Molecule
Fas Ligand
Tag
N-10×His
Expression System
HEK293
Expregion
Pro 134 - Leu 281
Endotoxin Level
0.1 EU per μg
Buffer
PBS, pH7.4
